As for the 49ers, they have six players out of the lineup, including wide receiver Ted Ginn is out with ankle issues while running backs LaMichael James and Brandon Jacobs will both be sidelined by injuries as well. Here is the complete list of inactives for San Francisco.
Kickoff between the two teams is set for 8:20 p.m. ET.
Stay with this StoryStream for full coverage leading up to Detroit's showdown with San Francisco. For more on the Lions, check out Pride Of Detroit. For more on the 49ers, please make sure to visit Niners Nation.