Starting pitcher Doug Fister has given up eight hits and three home runs already on Wednesday night, after giving up four home runs all of last season.
The first two home runs came from David Murphy. He hit a three-run shot in the second inning and a solo shot in the fourth.
Ian Kinsler hit a two-run shot shortly after Murphy's in the fourth inning.
The Tigers' three runs came off a Miguel Cabrera RBI single in the third, a Brennan Boesch RBI single in the fourth and an RIP triple from Quintin Berry in the fifth.