Boston was the first on the scoreboard thanks to a Cody Ross RBI-single in the first inning. The Tigers tied it up on a Brennan Boesch RBI-single in the fourth.
In the fifth, Detroit exploded with five runs, including back-to-back home runs from Miguel Cabrera and Prince Fielder. Boston pitcher Aaron Cook was taken out after the flurry -- he gave up nine hits and six runs in four and two-thirds innings.
Tigers pitcher Rick Porcello (8-6) started strong, but gave up singles to Dustin Pedroia, Adian Gonzalez, Ross and Will Middlebrooks in the sixth inning. This resulted in three runs and Porcello was replaced by Phil Coke.
The Tigers will begin a three-game home series against the Cleveland Indians on Friday.