Rookie Andre Drummond scored a career-high 22 points and the Pistons saw a surge in productivity when pairing him with Greg Monroe, but the Pistons lost their sixth-straight game Friday, 105-94 to Oklahoma City.
Monroe added 14 points, and Tayshaun Prince had 16 in the loss.
Detroit (0-6) sits one loss shy of matching the worst starts in franchise history in 1962 and 1980. They finish a six-game road trip Saturday at Houston. Detroit and Washington (0-4) are the only winless teams in the NBA.
Central Division-leading Milwaukee defeated Washington 101-91, after trailing 12-0 in the first quarter. Monta Ellis had 22 points in the win.
Chicago (3-2) was defeated by Oklahoma City 97-91 Nov. 8 and take on Northwest Division-leading Minnesota Saturday. Cleveland dropped its fourth game in its last five, 107-105 to Phoenix.
Indiana (2-4) lost a 96-94 nail-biter at Minnesota, losing on a Chase Budinger lay-up with one second left.