The Clippers, who will also host New Jersey on the quick homestand, dropped all four games on their recent road trip against Western Conference teams, including Wednesday's 107-95 setback at San Antonio.
Rasual Butler scored 18 points and Craig Smith provided 15 off the bench for Los Angeles, which has lost 18 in a row to the Spurs and fell to 1-8 on the season. Ryan Gomes, Blake Griffin and Eric Bledsoe all had 11 points in defeat.
"Our spacing has to be a little bit better," Clippers head coach Vinny Del Negro said.
Detroit will continue its four-game western road trip this evening and had a two-game winning streak stopped with Tuesday's 100-78 loss at Portland.
Rodney Stuckey finished with 17 points and Austin Daye added 15 points and eight rebounds for the Pistons, who had won two straight following an 0-5 start to the 2010-11 season. Tayshaun Prince was the only other scorer in double figures with 10 points.
"We didn't start off the right way in the third period," Pistons head coach John Kuester said. "You have to continually realize that when you're on the road you're mental toughness has to be paramount."
The Pistons had 17 turnovers and were outrebounded by a 45-33 margin. They are 0-4 away from The Palace this season and will also visit Sacramento and Golden State on the road swing. Detroit is off to its worst start away from home since dropping its first six in 1995-96.
Los Angeles won both meetings with the Pistons a season ago, but Detroit is 14-3 in the previous 17 matchups between the teams. The Pistons have won 10 of their last 14 at the Clippers.