Verlander (10-5) allowed seven hits, a run and walked a batter to win for the fifth time in six starts. He is the first Tigers pitcher to post a double- digit win total in at least five straight seasons since Frank Tanana (1985-89).
Brandon Inge drove in three runs for Detroit, which won for the 12th time in its last 13 games at Comerica Park, moving to an American League-best 27-11 at home.
Jason Vargas (6-4) dropped his second consecutive start after yielding eight hits and six runs over 4 1/3 innings.
Michael Saunders singled in the only run for the Mariners, who lost their third in a row. They've been outscored 13-2 thus far in this series.