Matt Stafford played three quarters and went 13-of-17 for 141 yards and one score for the Lions, who have won two of three exhibition matches.
Kevin Smith also rushed for a touchdown, while Calvin Johnson led the receiving corps with 42 yards on a pair of catches. Bryant Johnson recorded a seven-yard TD reception and Chris Houston returned a fumble 14 yards for another score.
The Browns lost defensive back Nick Sorensen to an unknown injury in the second quarter. He had to be removed from the field on a stretcher with a backboard after a pair of Lions hit him during kickoff coverage. He was taken to a local hospital for evaluation.