The Pistons had a chance to regain the lead, but Rodney Stuckey lost the ball out of bounds while driving the lane.
Austin Daye hit a baseline jumper with 11.1 seconds left to give the Pistons a 101-100 lead, but Rush came streaking down the lane and flushed home a pass to give the Pacers the lead back.
Greg Monroe's 27-point, 12-rebound effort was wasted as the loss pushed Detroit further out of the playoff picture. The Pistons (21-38) came into the game trailing the Pacers (26-30) by five and a half games for the final playoff spot in the Eastern Conference. The Pistons are now 7-22 on the road this season.
Tracy McGrady added a double-double of his own with 16 points and 12 assists for the Pistons, who trailed by as many as 16 twice in the ball game. Stuckey added 21 points but turned the ball over six times, the last one being the most costly
Tyler Hansbrough led five Pacers in double digits with 21 points and 12 rebounds. Danny Granger added 18 points.