The Pistons were outscored 24-9 in the fourth quarter, turning a mildly competitive game into an embarrassing one.
The dynamic duo of Derrick Rose (22 points and 8 assists) and Carlos Boozer (23 points and 8 rebounds) propelled Chicago to the win
Rookie Brandon Knight started at point guard in place of Rodney Stuckey (groin) and scored 13 points on 6-10 shooting along with 5 rebounds and one assist.
With the loss, Detroit falls to 0-4 on the road, and they have lost all four of those games by at least 11 points.
The Pistons return home to host the Dallas Mavericks on Tuesday night in a game scheduled to start at 8:00 p.m. eastern.