Andrew Ladd also notched a goal and assist in the win. Chris Thorburn, Anthony Stewart and Dustin Byfuglien each tallied a goal for Atlanta, which has won three in a row for the first time all season.
Ondrej Pavelec was solid between the pipes with 32 saves in the win.
The Thrashers drew first blood during the opening three minutes of the game when Eric Boulton curled around the back of the net and centered it to Thorburn, who went top shelf past Howard.
They jumped to a 2-0 lead on a shorthand goal about nine minutes later. Rich Peverley broke loose on the right side to find an open Ladd, who poked it into the net.
Still under the powerplay, the Red Wings answered back 19 seconds later when Niklas Kronwall moved the disc at the top of the point to Mike Modano, who passed the puck through the zone to find Bertuzzi in the slot for the goal.
Atlanta regained its two-goal lead, 3-1, early in the second period on a powerplay that spilled over from the first period. Johnny Oduya corralled the puck near the left side boards and pushed it ahead to Little, who found a wide-open Stewart on the opposite side to put the puck past a diving Howard.
The lead was extended to three with 3:35 left in the second, when Evander Kane intercepted a Detroit pass at center ice. He pushed it forward to Little, who broke free and rushed down the left side to rip it past the Detroit goaltender.
Atlanta tacked on a late third period goal on a 4-on-3 powerplay goal when Byfuglien slapped a one-timer from the point. Ladd and Tobias Enstrom set up the score during the advantage.
The Red Wings have taken four of the six series meetings...Atlanta outshot Detroit 38-33.. Joey MacDonald started the third period in place of Howard. He ended with seven saves on eight shots...It was Atlanta's fourth game of a six game homestand.