MacLean was hired by the Senators this past June to replace the fired Cory Clouston after the team missed the playoffs for the second time in three seasons and finished dead last in the Northeast Division.
He had served as an assistant under Mike Babcock in Detroit for the past six seasons and won a Stanley Cup with the team in 2008.
However, his former squad roughed up his new team as Todd Bertuzzi, Cory Emmerton, Nicklas Lidstrom, Jiri Hudler and Ian White all had goals for the Red Wings, who were eliminated by San Jose in seven games in the conference semifinals last season.
Jimmy Howard stopped 29-of-32 shots in the winning effort.
The Red Wings took the lead with 3:59 to play in the first after Darren Helm sent a pass through the middle for Bertuzzi, who was behind the defense and snapped a shot into the right corner.
Just 99 seconds into the second, an Ottawa giveaway saw Lidstrom get the puck at the left circle and from down low he chipped it past Anderson.
Another Ottawa turnover behind the net saw Detroit take advantage as Drew Miller picked the puck off a Senator and centered it for Emmerton, who had the easy slam at the 9:40 mark.
Just 58 seconds later, Pavel Datsyuk picked the puck off a defender in the high slot and slid it over to the right circle for Hudler, who lifted a backhand over the glove of Anderson for a 4-0 lead.
White scored at the 3:12 mark of the third to make it a 5-0 contest.
Michalek had an even-strength goal at the 5:49 mark and followed that with a power-play marker 2 1/2 minutes later.
Kuba's goal came with 1:31 left in the game on the power play to account for the final score.
The Red Wings have won four straight games against Ottawa...Detroit plays in Colorado on Saturday...Ottawa plays at Toronto on Saturday...Ottawa went 2- for-3 on the power play while Detroit was 0-for-5...Miller finished with two assists for Detroit while Jason Spezza had two helpers for Ottawa.