Verlander (11-3) pitched seven strong innings, giving up one run on seven hits while fanning six.
Mike Pelfrey (4-7) was tagged with the loss, surrendering five runs -- four earned -- on eight hits in just 4 2/3 innings.
Detroit scored three runs in the third inning to jump out to a 4-1 lead. Victor Martinez doubled to right-center then moved to third on a Dirks single. Jhonny Peralta then drew a walk to load the bases for Alex Avila, who knocked in Martinez with a sacrifice-fly to left. With runners on first and second, Ramon Santiago ripped a single to center to score Dirks. Peralta was also able to score on the play after Angel Pagan's wild throw skipped past Murphy at third.
The Tigers were able to add another run in the fifth, after Dirks blasted a 2-1 sinker into the right-field stands.
Following a scoreless first inning, Murphy put the Mets on the board with a leadoff home run that barely cleared the right-field wall.
The Tigers managed to even the score in the bottom-half of the second with an RBI single from Jackson. Peralta led off with a base hit through the hole at short, then moved to second on a hit-and-run that resulted in a groundout. Jackson followed with the single to right to plate Peralta.
The Mets added one run in the eighth on a Carlos Beltran homer, but Detroit's relief effort proved to be too much.
Detroit pitcher Phil Coke was moved to the bullpen; Charlie Furbush will take his spot in the starting rotation...Verlander joined C.C. Sabathia as the only 11-game winners in 2011... Reyes had his 42nd multi-hit game of the season...Willie Harris, who left the Mets on paternity leave, was placed on the bereavement list after losing his newborn baby.