He hurt his left hamstring in the fifth inning, running from first to second base on an Austin Jackson fly ball, via Chris Iott of mlive.com.
Laird grabbed the hamstring after sliding into second base and then left the field, replaced by rookie Bryan Holaday.
It's interesting timing, as the Tigers are slated to bring catcher Alex Avila back from Triple-A Toledo on Thursday. He has been on the disabled list with his own hamstring injury since June 6. It was assumed that Holaday would be sent down to the minors to make room for Avila, but if this injury to Laird turns out to be serious then there could be a change of plans.