The Lions go into the game looking for their third win in their last four games while the Jaguars are trying to end a four-game losing streak. Jacksonville has already played the other three NFC North teams, losing to Green Bay, Minnesota and Chicago.
The Lions are led by quarterback Matthew Stafford, who is completing 63 percent of his passes for 2,108 yards, eight touchdowns and seven interceptions. Stafford has led late comeback wins over Philadelphia and Seattle in the last three weeks.
The Lions will try to get wide receiver Calvin Johnson going. Johnson has caught 41 passes for 638 yards, but he has just one touchdown this season after scoring 16 last season.
Jacksonville quarterback Blaine Gabbert has passed for 1,209 yards, seven touchdowns and three interceptions this season. Running back Maurice Jones-Drew has rushed for 414 yards and one touchdown.
The Lions are favored by four points.