The Detroit Lions' cornerback was grabbing his left knee after tackling Arizona receiver Larry Fitzgerald on a screen pass. He limped off the field under his own power but was carted to the locker room.
Coming into the game at University of Phoenix Stadium, Lacey was listed as probable with a foot and Achilles injury. He recorded two tackles before leaving the game.
The fourth-year pro out of Oklahoma State has 34 tackles and an interception on the season.
But the Lions' defense has fared well against the struggling Cardinals offense without the cornerback and with a defensive line missing tackle Nick Fairley, who was listed as inactive prior to the game.
Though Arizona quarterback Ryan Lindley went 5-for-6 passing to start, he was picked off on the first pass of the Cardinals' second possession by linebacker DeAndre Levy.