Saturday looks to be the fourth consecutive game the Cavs will play without its young backcourt duo of Kyrie Irving (index finger) and Dion Waiters (ankle).
It'll be the second straight time the Pistons (6-15) get a chance to face them at their low point.
Detroit defeated Cleveland 89-79 on Dec. 3, the first of three games Waiters would miss. It's likely the fourth will come Saturday. The Cavs are reeling from a four-game losing streak, having only one two of their last 10 games. Those 10 have all been without Irving, who hasn't played since Nov. 18.
Detroit is coming off a tough loss at home against Chicago, as Joakim Noah scored a career-high 30 points and grabbed 23 rebounds - another career high - in the Bulls' 108-104 win Friday. It was Chicago's 16th consecutive win at the Palace at Auburn Hills.
The Pistons have lost four of their last five games, surrendering over 100 points in their last two, including a 104-97 loss to Golden State.
Tipoff is scheduled for 7:30 p.m. ET from Quicken Loans Arena in Cleveland.