The Pistons are now 13-22 on the season and just 3.5 games behind the Boston Celtics for the eighth and final playoff spot in the Eastern Conference.
The Bobcats have lost 19 of their last 20 games after starting the season with a 7-5 record.
Kemba Walker is averaging 17.8 points, 6.0 assists and 1.8 steals per game, leading the Bobcats in all three categories.
The meeting between the two teams also marks the return of Ben Gordon to Detroit for the first time since being traded to Charlotte in the off-season. Gordon is averaging 13.4 points off the bench for the Bobcats this season.